HIV

 NRTIs

Emtricitabine, lamivudine, tenofovir, abavcavir

NRTIs - nucleoside reverse transcriptase inhibitors

Abacavir (ABC) ziagen, test HLA B5701, delayed type 4 hypertensitivity

Emtricitabine Emtriva

Tenofovir (sir Tristan) - viread

zidovudine -

stavudine

didanosine

Lamuvudine (sir lancelot)

hep B banner - Tenofovir and lamivudine

backbone 2 NRTIs + base integrase inhibitor or protease inhibitor

Protease inhibitor

- not phosphorylated

- Ritonavir CYP inhibitor Right on a vir - boosts other cyp inhibitors

- indinavir - kidney injury, must hydrate, inhibitor 

rifampin activates CYP 450 and decreases concntreation of other protease inhibitors

POL - codes for HIV enzyme protease

Cuinevere - protease inhibitor, lipodystrophy, dyslipidemia, hyperglycemia due to insulin resistance

Integrase inhibitor

- raltegravir viral integrase

GP41, GP120

CCR5, miraviroc binds CCR5 which HIV uses for entry

enfuvirtide GP41

dolutegravir, cabotegravir

NRTIs affect insulin resistance

PEP start w/in 72 hrs start for 28 days

three days to treat

1 week to 3-4 weeks to late to start PEP, too early to test positive

HIV doesn't turn positive until 3-4 weeks.

NAAT 10 - 33 days

Antigen 18 days 3 weeks

waiting game for 3-4 weeks where you don't know if they are positive or not.

Truvada - tenofovir, emtricitabine

tenofovir fumarate

TDF - disparate

turvada is tenofovir disparate

disoproxyl

tenofovir fumarate + emtricitabine

Discovy - tenofovir, TAF

tenofovir alafenamide

two that are used typically

caletegravir - injection

Truvada is associated with renal issues more so. 

Discovy more associated with bone issues, share the same side effect profile.

celetegravir other medication + injection into the butt and shoulder once a month

truvada and discovy are taken daily.

HIV most will contain tenofovir and emtricitabine, different combinations that truvada and discovy.

HIV will biktarvy tenofovir emtricitabine 

bictagrevir

general motif, for first line HIV treatment medications

Tenofovir, emtricitabine and two other things.

one or two pills a day, 4-5 medications a day.

What medications to start someone on, what is dosing?

Biktarvy more popular one time medications. Not treatment naive. 

Noncompliant, lost insurance 

2nd and third line.

enfuvirtide GP 41, powerful, lots of resistance

 compliance w/ HIV, on medications they do significantly better. 

On and off, and HIV builds resistance, no one knows a nightmare. 

Pregnant good luck, doesn't get it

Mother to die from HIV, kid has high risk of catching HIV, pregnancy going to be bloody. Open for C-section going to be shock. Open them up for C-section.

viral load uncontrolled can do cesarean give zidovudine right before delivery.

low then can do vaginal. 

zidovudine