fluoroquinolones predispose to c diff
amox clav
higher risk for c diff
use first line like nitrofurantoin and trimethoprim sulfamethoxazole
amoxicillin can be used
nitrofurantoin in elderly and reduced egfr
beta lactams can be empiric treatment in patients with positive urinalysis
fosfomycin for uti
fosfomycin better for MDR e. coli
fosfomycin is not good for other drugs other than e/ coli UTI
other gram negative are killed by fosfomycin
certainly some confounding
best niche for fosfomycin
definitive treatment
short 3 day low dose 250mg PO BID therapy w/ comparable to superior efficacy
ciprofloxacin low potential for QTc prolongation and serious ventricular arrhythmia
black box
treat acute cystitis
recurrent UTI
talk about maximally trying to prevent other UTIs
what not to use
meaningful reduction in cystitis in previous year
prevention
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