NHLBI - NAtional HEart Lung Brain Institute

Acute Respiratory Distress Network (ARDSNet) Studies 06 and 08 Prospective, Randomized, Multicenter Trial of Aerosolized Albuterol Versus Placebo for the Treatment of Acute Lung Injury (ALTA)	ARDSNet-ALTA	Specimens and Study Datasets	Open BioLINCC Study
Acute Respiratory Distress Network (ARDSNet) Study 04 Assessment of Low tidal Volume and elevated End-expiratory volume to Obviate Lung Injury (ALVEOLI)	ARDSNet-ALVEOLI	Specimens and Study Datasets	Open BioLINCC Study
Acute Respiratory Distress Network (ARDSNet) Studies 01 and 03 Lower versus higher tidal volume, ketoconazole treatment and lisofylline treatment (ARMA/KARMA/LARMA)	ARDSNet-ARMA/KARMA/LARMA	Specimens and Study Datasets	Open BioLINCC Study
Acute Respiratory Distress Network (ARDSNet) Studies 07, 08, 09, 11, and 12 Early Versus Delayed Enteral Feeding to Treat People with Acute Lung Injury or Acute Respiratory Distress Syndrome (EDEN)	ARDSNet-EDEN	Specimens and Study Datasets	Open BioLINCC Study
Acute Respiratory Distress Network (ARDSNet) Study 05 Fluid and Catheter Treatment Trial (FACTT)	ARDSNet-FACTT	Specimens and Study Datasets	Open BioLINCC Study
Acute Respiratory Distress Network (ARDSNet) Study 02 Late Steroid Rescue Study (LaSRS)	ARDSNet-LaSRS	Specimens and Study Datasets	Open BioLINCC Study
Acute Respiratory Distress Network (ARDSNet) Studies 07 and 08 Prospective, Randomized, Blinded, Placebo-controlled, Multi-center Trial of Omega-3 Fatty Acid, Gamma-Linolenic Acid, and Anti-Oxidant Supplementation in the Management of Acute Lung Injury or Acute Respiratory Distress Syndrome (Omega)	ARDSNet-Omega	Specimens and Study Datasets	Open BioLINCC Study
Acute Respiratory Distress Network (ARDSNet) Studies 10 and 12 Statins for Acutely Injured Lungs from Sepsis (SAILS)	ARDSNet-SAILS	Specimens and Study Datasets	Open BioLINCC Study

Outline of ARDSNet Studies

I. Overview of ARDSNet

A. Purpose and focus on acute lung injury and acute respiratory distress syndrome (ARDS)

II. Key Studies

A. ARDSNet-ALTA 1. Studies 06 and 08 2. Design: Prospective, randomized, multicenter trial 3. Comparison: Aerosolized albuterol vs. placebo 4. Data: Specimens and study datasets available via Open BioLINCC Study

B. ARDSNet-ALVEOLI 1. Study 04 2. Focus: Assessment of low tidal volume and elevated end-expiratory volume 3. Objective: Obviate lung injury 4. Data: Specimens and study datasets available via Open BioLINCC Study

C. ARDSNet-ARMA/KARMA/LARMA 1. Studies 01 and 03 2. Focus: Lower vs. higher tidal volume, ketoconazole treatment, and lisofylline treatment 3. Data: Specimens and study datasets available via Open BioLINCC Study

D. ARDSNet-EDEN 1. Studies 07, 08, 09, 11, and 12 2. Objective: Early vs. delayed enteral feeding for treating acute lung injury/ARDS 3. Data: Specimens and study datasets available via Open BioLINCC Study

E. ARDSNet-FACTT 1. Study 05 2. Focus: Fluid and Catheter Treatment Trial 3. Data: Specimens and study datasets available via Open BioLINCC Study

F. ARDSNet-LaSRS 1. Study 02 2. Focus: Late Steroid Rescue Study 3. Data: Specimens and study datasets available via Open BioLINCC Study

G. ARDSNet-Omega 1. Studies 07 and 08 2. Design: Prospective, randomized, blinded, placebo-controlled, multicenter trial 3. Intervention: Omega-3 fatty acid, gamma-linolenic acid, and antioxidant supplementation 4. Objective: Management of acute lung injury/ARDS 5. Data: Specimens and study datasets available via Open BioLINCC Study

H. ARDSNet-SAILS 1. Studies 10 and 12 2. Focus: Statins for acutely injured lungs from sepsis 3. Data: Specimens and study datasets available via Open BioLINCC Study